From ESPN:
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Colts starting left tackle Anthony Castonzo had a "minor" setback with his hamstring and will miss Sunday's game at Washington, coach Frank Reich said Friday. Castonzo did not practice Thursday or Friday after being limited in practice Wednesday. He originally injured his hamstring in the first week of training camp in early August. The Colts are dealing with injures at tackle. J'Marcus Webb, who started at right tackle in Week 1, was placed on injured reserve earlier this week with a hamstring injury. Joe Haeg started at left tackle in Week 1. The Colts could go with rookie Braden Smith or Le'Raven Clark at right tackle or slide Haeg to right tackle and play Smith or Clark at left tackle.
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Monday they will release the news his leg was amputated